While I've already included a few games that epitomize choice in games, Heavy Rain, does so in a manner unlike any of the others, because the entire game is about choice and consequences with interweaving stories that come together to tell a larger narrative.
In Heavy Rain, players take control of four characters mixed up in the case of the Origami Killer: Ethan Mars, a father who is trying to rescue his son from the killer; Scott Shelby, a private investigator on trail of the Origami Killer; Norman Jayden, a FBI profiler who is tracking down the Killer in his own way; and Madison Paige an investigative journalist. These characters each follow their own leads and face separate trials along the way, which can completely change them, sending repercussions throughout the story, or even lead to a character's death. The number of scenarios in this game is pretty incredible with several different outcomes to each scene, sometimes as the result of a minute detail, and even once the case is solved, it's well worth running through again to witness different results.
These characters also do a great job of tugging at your heart strings. Ethan's story in particular was really powerful for me, as he can go through hell in order to get his son back. I heavily sympathized with Ethan's exhaustion and sacrifices as he was drained more and more as the game progressed (at least the way I pushed him.)
I've got mixed feelings about the gameplay in Heavy Rain. It's essentially a game built on quick time events (QTEs) using the control sticks as well as the buttons (or the Move controller if you're so inclined). This kind of gameplay can be picky about its inputs, and at times tedious, but overall it helps root the player in the story, especially since many of these actions and conversations are time sensitive, resulting in those less than ideal results if things don't go well or decisions are not quickly made. I think this system could be improved upon, but as an experimentally step forward with regards to cinematic gameplay I think it was a right step. While of their games, Heavy Rain is the only Quantic Dream game to make my “Required Reading” list, their other game Farenheit or Indigo Prophecy is well worth playing, even if it's a bit rougher around the edges, and their upcoming game Beyond has a strong chance to make it onto the “Required Reading” list.